Inhibition of rat liver glucose-6-phosphate dehydrogenase synthesis by glucagon.

Inhibition of Human Erythrocyte Glucose 6-Phosphate Dehydrogenase by Cadmium, Nickel and Aluminium

Regulation of glucose synthesis in hormone-sensitive isolated rat hepatocytes.

A simplified procedure was developed for isolation of intact, hormone-sensitive liver cells in a high and reproducible yield. These cells produce glucose from various precursors at rates comparable to those achieved in isolated perfused liver. Glucagon enhanced glucose synthesis from pyruvate, dihydroxyacetone, fructose, or xylitol more effectively at low than at high substrate concentration. A...

The Journal of Biological Chemisthy

In fasting-refeeding experiments glucagon was found to inhibit the induction of rat liver glucose-&P dehydrogenase. The kinetics of induction in the presence of glucagon indicated that the hormone decreased the rate of enzyme synthesis without altering the rate of enzyme degradation. Immunochemical titration of the amount of glucose-6-P dehydrogenase protein present in control and glucagon trea...

Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in adult rat liver

Malic enzyme (ME, EC 1.1.1.40) and glucose-&phosphate dehydrogenase (G6PD, EC 1. I . 1.49) are lipogenic enzymes, whose activities correlate positively with the rate of de novo fatty acid synthesis. The activities of these enzymes are high in livers of well-fed animals and low in starved ones (Wakil et ul., 1983). A number of nutritional and hormonal agents have been examined as regulators of t...

The effect of substitution at C-2 of D-glucose 6-phosphate on the rate of dehydrogenation by glucose 6-phosphate dehydrogenase (from yeast and from rat liver).

1. The deoxyfluoro-d-glucopyranose 6-phosphates are substrates for both yeast and rat liver glucose 6-phosphate dehydrogenase. 2. The V(max.) values (relative to d-glucose 6-phosphate) were determined for a series of d-glucose 6-phosphate derivatives substituted at C-2. The V(max.) values decreased with increasing electronegativity of the C-2 substituent. This is consistent with a mechanism inv...